Question

Which of the following is a result of a sense mutation?

(a) Sickle cell anemia

(b) Thalassemia

(c) Mutation in beta globin leading to abnormal clotting and bleeding

(d) Down’s syndrome

I got this question in an online quiz.

The question is from DNA Mutation topic in division DNA Mutation, DNA Repair, Transposable Elements of Cytogenetics

Answer 1

The correct answer is (b) Thalassemia

Explanation: In Thalassemia the alpha globin is 141 amino acids long as the UAA codon is changed to CAA, i.e a stop codon is changed to a glutamic acid. While sickle cell anemia is due to a mis sense mutation and c is due to a nonsense mutation and d due to trisomy.