Question

You are studying a mutational hot spot in the promoter region of a gene. Which type of mutation will you expect the most in this case?

(a) Deamination

(b) Depurination

(c) Methylation

(d) Frame shift

I had been asked this question in an online interview.

The origin of the question is DNA Mutation topic in portion DNA Mutation, DNA Repair, Transposable Elements of Cytogenetics

Answer 1

Right answer is (a) Deamination

To elaborate: Mutational hot spots are regions which are rich in 5MC and these on deamination give a T base. Under normal condition deamination of C gives a U which is spontaneously excised out, but as T is a normal DNA base the mutation is fixed.