Question

Sickle cell anemia is a result of _______________

(a) Non sense mutation

(b) Mis-sense mutation

(c) Sense mutation

(d) Frame shift mutation

I had been asked this question in an online quiz.

My doubt stems from DNA Mutation topic in portion DNA Mutation, DNA Repair, Transposable Elements of Cytogenetics

Answer 1

Correct option is (b) Mis-sense mutation

Best explanation: In this disease, a GAG is converted to a GUG, i.e a glutamic acid is converted to a valine. This is example of a mis-sense mutation where a change of base codes for a different amino acid from the original.