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A frame shift mutation will have minimum effect when it leads to ______________

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A frame shift mutation will have minimum effect when it leads to ______________

(a) Insertion of 2 bases

(b) Deletion of 1 base

(c) Insertion of 3 bases

(d) Deletion of 2 bases

The question was asked during an online exam.

The doubt is from DNA Mutation in division DNA Mutation, DNA Repair, Transposable Elements of Cytogenetics

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Best answer
Right answer is (c) Insertion of 3 bases

For explanation: Frame shift mutations lead to lease effect when they lead to an insertion or deletion of 3 bases, as due to our codon being triplet this doesn’t shift the reading frame. However, if the codon thus lost or added is a very important one in the gene, there could be serious consequences.

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