Question

Which of the following will be the slowest step in tablet drug absorption?

(a) Tablet disintegration to granules

(b) Granules disintegration to fine particles

(c) Fine particles dissolution

(d) Dissolution absorbed into the blood

I have been asked this question in an international level competition.

This intriguing question comes from Drugs Absorption topic in chapter Absorption of Drugs of Drug Biotechnology

Answer 1

Right option is (a) Tablet disintegration to granules

For explanation: The rate at which drug will be getting absorbed from the drug from the blood depends upon the drug formulation. In the case of a tablet, the disintegration of the tablet into smaller particles will be the slowest step.