Question

For oral formulation, what should be the minimum aqueous solubility to avoid bioavailability problems?

(a) 0.9%

(b) 1%

(c) 2%

(d) 0.11%

The question was posed to me in an online quiz.

Origin of the question is Drugs Absorption in section Absorption of Drugs of Drug Biotechnology

Answer 1

Right option is (b) 1%

For explanation I would say: Experiments have shown that a drug should have a minimum aqueous solubility of 1% to avoid bioavailability problems. Lesser than that it becomes a very serious issue for the drug to dissolve and give the proper effect.