Question

What should be the ideal solubility rate of an orally administered drug in the pH range of 2 to 8?

(a) 3-4mg/ml

(b) 4-6 mg/ml

(c) 7-8 mg/ml

(d) 1-2 mg/ml

This question was posed to me in an interview for job.

My question is from Physicochemical Factors Affecting Drug Absorption in section Absorption of Drugs of Drug Biotechnology

Answer 1

Right choice is (d) 1-2 mg/ml

To elaborate: The solubility of any orally administered drug should be between 1-2 mg/ml in the range of pH 2-8. The solubility becomes a great matter of concern if it is less than that. And if more than that the dosage must be carefully calculated.