Question

Which sentence will define the Dissolution rate?

(a) Amount of solid substrate that goes into solution under constant time

(b) Amount of solid substrate that goes into solution under constant time under standard temperature

(c) Amount of solid substrate that goes into solution under constant time under standard temperature, pH, and pressure

(d) Amount of solid substrate that goes into solution under constant time under standard temperature, pH, solvent composition and constant surface area

I got this question in semester exam.

My question is taken from Physicochemical Factors Affecting Drug Absorption topic in portion Absorption of Drugs of Drug Biotechnology

Answer 1

Right option is (d) Amount of solid substrate that goes into solution under constant time under standard temperature, pH, solvent composition and constant surface area

To explain: Dissolution rate is defined as the amount of solid substrate that goes into solution under constant time under standard temperature, pH, solvent composition and constant surface area. It is a dynamic process. Drugs having poor aqueous solubility have less dissolution rate.