Question

Which of the DNA polymerase in eukaryotes is responsible for repair synthesis of the excised strand in NER?

(a) Pol epsilon

(b) Pol III

(c) Pol beta

(d) Pol I

This question was posed to me in an online interview.

My doubt stems from Repair of DNA Damage: NER, Direct Reversal in portion DNA Mutation, DNA Repair, Transposable Elements of Cytogenetics

Answer 1

Correct answer is (a) Pol epsilon

To elaborate: Major polymerase in eukaryotes is pol delta and pol epsilon. So, they are responsible of repair synthesis of the excised out patch in NER.