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It is good that Guanine methyl transferase is absent in human beings.

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It is good that Guanine methyl transferase is absent in human beings.

(a) True

(b) False

I had been asked this question in a national level competition.

This interesting question is from Repair of DNA Damage: NER, Direct Reversal topic in section DNA Mutation, DNA Repair, Transposable Elements of Cytogenetics

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Correct choice is (a) True

For explanation: While de-alkylating agents could lead to the direct reversal of the damages, yet it is a suicide protease. One molecule is irreversibly inactivated in correcting single methylation damage. It is wasteful, and eukaryotes have better ways of taking care of the methylation like BER.

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