Question

What is the equation for bioavailability?

(a) [AUC]std Dstd τtest / [AUC]test Dtest τstd

(b) [AUC]test Dtest τstd / [AUC]std Dstd τtest

(c) [AUC]test Dstd τtest / [AUC]std Dtest τstd

(d) 1 / [AUC]std Dtest τstd

This question was posed to me by my college director while I was bunking the class.

My question is based upon Bioavailability topic in section Compartment Modelling, Non Linear Pharmacokinetics, Bioavailability and Bioequivalence of Drug Biotechnology

Answer 1

Correct answer is (c) [AUC]test Dstd τtest / [AUC]std Dtest τstd

To explain I would say: The equation of bioavailability is [AUC]test Dstd τtest / [AUC]std Dtest τstd, D stands for dose administered, test and std indicate the test and standard doses of the same drug to determine the relative availability. The dosing interval is τ.