Question

Which of the following is used in solid solutions method of enhancing bioavailability?

(a) Highly water-soluble compound

(b) Organic solvent

(c) Inorganic clays like bentonite

(d) Creating metastable polymorphs

The question was posed to me during an interview for a job.

The query is from Bioavailability topic in chapter Compartment Modelling, Non Linear Pharmacokinetics, Bioavailability and Bioequivalence of Drug Biotechnology

Answer 1

Right choice is (a) Highly water-soluble compound

To explain I would say: There are three different ways of solid solutions these are the use of the solid solution, use of eutectic mixtures, and the use of solid dispersions. In all these cases the solute or the drug is most of the times not soluble in water acts as a guest and the solvent used is highly water-soluble compound or polymer acting as a host or carrier.