Question

Which of the following is not an approach for overcoming bioavailability problems?

(a) Pharmaceutic approach

(b) Pharmacokinetic approach

(c) Biologic approach

(d) Partition coefficient approach

I had been asked this question during an online exam.

My question is taken from Bioavailability topic in division Compartment Modelling, Non Linear Pharmacokinetics, Bioavailability and Bioequivalence of Drug Biotechnology

Answer 1

Right answer is (d) Partition coefficient approach

The explanation is: There are three approaches in overcoming the bioavailability problems these are the pharmaceutic approach, pharmacokinetic approach, and biologic approach. The pharmaceutic approach involves modification of formulation, manufacturing processes. The pharmacokinetic approach is in which the pharmacokinetics of the drug is altered by modifying its chemical structure. The biologic approach is where the route of administration can be changed.