Question

A drug with poor stability means higher bioavailability.

(a) True

(b) False

The question was posed to me in exam.

The doubt is from Bioavailability topic in chapter Compartment Modelling, Non Linear Pharmacokinetics, Bioavailability and Bioequivalence of Drug Biotechnology

Answer 1

The correct answer is (b) False

The explanation is: Poor stability of the drug at physiological pH causes the difference in its disintegration, dissolution rate thus decreasing the bioavailability. The drug can also have poor stability of the dissolved drug at the patient’s body pH, inadequate partition coefficient, and extensive presystemic metabolism.