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Which of the following is not measured in acute pharmacological response study?

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Which of the following is not measured in acute pharmacological response study?

(a) ECG

(b) EEG

(c) Pupil diameter

(d) Serum drug level

The question was asked in an online quiz.

Question is taken from Bioavailability topic in portion Compartment Modelling, Non Linear Pharmacokinetics, Bioavailability and Bioequivalence of Drug Biotechnology

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Right option is (d) Serum drug level

The explanation: When bioavailability measurement using pharmacokinetic processes are difficult, inaccurate, non-reproducible, acute pharmacological effect such as a change in ECG, EEG, pupil diameter, etc. is related to the time course of a given drug. Bioavailability can then be calculated by construction the pharmacologic effect-time curve as well as dose-response graphs.

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