Question

In the below picture which form of solid solution of griseofulvin with succinic acid is shown?

(a) Solid solution

(b) Eutectic mixture

(c) Micronized drug

(d) Coarse drug

The question was asked in class test.

My doubt is from Bioavailability in portion Compartment Modelling, Non Linear Pharmacokinetics, Bioavailability and Bioequivalence of Drug Biotechnology

Answer 1

Right answer is (d) Coarse drug

Best explanation: Solid solutions are prepared by fusion method where a mixture of solute and solvent are melted together followed by rapid solidification. Such systems are prepared by fusion and are called as melts e.g. griseofulvin-succinic acid. A solid solution is a binary system with solid solute dispersed in a solid solvent. Eutectic mixtures are physically blended mixture of two crystalline compounds.