Question

Which of the following is not an important parameter of plasma level time studies?

(a) Cmax

(b) Tax

(c) The area under the plasma level-time curve

(d) Steady state level

This question was addressed to me in quiz.

I would like to ask this question from Bioavailability topic in chapter Compartment Modelling, Non Linear Pharmacokinetics, Bioavailability and Bioequivalence of Drug Biotechnology

Answer 1

The correct option is (d) Steady state level

Easiest explanation: Cmax is the peak plasma concentration which shows whether the drug is being absorbed systemically so that it can be able to provide a therapeutic response. Tmax is the peak time which will give the indication of the rate of absorption. The area under the plasma level-time curve gives the measure of the quantity of absorption of the drug that reaches the systemic circulation.