Question

What is polygenic control of drugs?

(a) Drug controlling seen in an individual

(b) Drug controlling seen in twins

(c) Drug controlling seen in between different species

(d) Drug controlling seen in a particular population

I have been asked this question in homework.

This interesting question is from Drugs Biotransformation topic in chapter Biotransformation of Drugs of Drug Biotechnology

Answer 1

The correct answer is (b) Drug controlling seen in twins

Best explanation: Polygenic control has been observed in twins. In identical twins that are monozygotic twins, there is very little or no difference in drug metabolism. It was detected that there was no difference in the metabolism of phenylbutazone, dicoumarol, and antipyrine. Although large variations were detected in dizygotic twins.