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M cyclin CDK _________________ cdc20 and ______________ Hct1?

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M cyclin CDK _________________ cdc20 and ______________ Hct1?

(a) Activates, activates

(b) Activates, inactivates

(c) Inactivates, activates

(d) Inactivates, activates

I had been asked this question in an online interview.

Asked question is from Cell Cycle Stages in section Cancer Biology & Methods in Cytogenetics of Cytogenetics

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Best answer
The correct choice is (b) Activates, inactivates

Best explanation: Both Cdc20 and Hct1 are APC ligases which help in escape from mitosis by destruction of M CDK, but cdc20 is activated by M cyclin – CDK by while Hct1 is inactivated by the same through phsphorylation.

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