Question

What is the function of Phosphatidylcholine in multienzyme mixed-function oxidase system, located in the endoplasmic reticulum?

(a) Oxidising the substrate

(b) Reducing the substrate

(c) Facilitate electron transfer from NADPH to cytochrome 450

(d) Facilitate electron transfer from cytochrome 450 to NADPH

The question was asked in semester exam.

This key question is from Drugs Biotransformation topic in portion Biotransformation of Drugs of Drug Biotechnology

Answer 1

Right choice is (c) Facilitate electron transfer from NADPH to cytochrome 450

Easy explanation: Phosphatidylcholine has choline as a head group. These are major components of the cell membrane. Phosphatidylcholine is a heat stable lipid component which functions to facilitate electron transfer from NADPH to cytochrome 450.