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Microsome are selective to ____________

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in Drug Biotechnology by (138k points)
Microsome are selective to ____________

(a) Water-soluble drugs

(b) Lipid soluble drugs

(c) Acidic drugs

(d) Basic drugs

This question was posed to me in a national level competition.

My question is taken from Drugs Biotransformation topic in chapter Biotransformation of Drugs of Drug Biotechnology

1 Answer

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Right answer is (b) Lipid soluble drugs

To elaborate: The intact Lipoidal membrane of the microsome is essential for its selectivity towards lipid soluble substrates. The lipid soluble substrate is bio transformed into water-soluble metabolite by the microsomal enzymes and thus can easily excrete out.

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