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Which organs comprise the central compartment in a two compartment model?

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Which organs comprise the central compartment in a two compartment model?

(a) Muscles

(b) Skin

(c) Adipose

(d) Liver

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This key question is from One & Two Compartment Open Model topic in division Compartment Modelling, Non Linear Pharmacokinetics, Bioavailability and Bioequivalence of Drug Biotechnology

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Right answer is (d) Liver

Explanation: The central compartment or the compartment 1 in a two compartment model comprises of the blood and the highly perfused tissues like liver, lungs, and kidneys, etc. which equilibrate blood rapidly. These compartments will have the elimination from them.

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