Question

In the given picture, the marking “b” represents the drug concentration of which compartment?

(a) The central compartment in a two compartment model

(b) The peripheral compartment in a two compartment model

(c) The central compartment in a one compartment model

(d) Drug concentration of the plasma

I got this question in class test.

I'd like to ask this question from One & Two Compartment Open Model in chapter Compartment Modelling, Non Linear Pharmacokinetics, Bioavailability and Bioequivalence of Drug Biotechnology

Answer 1

The correct answer is (b) The peripheral compartment in a two compartment model

The best explanation: In the graph, the marked curve is showing the drug concentration of the peripheral compartment of a two compartment model. The drug concentration in the peripheral compartment first increases and reaches the maximum. Then due to loss of drug starts due to elimination. This is the post distributive or elimination phase.