Question

In the equation log C = log Co – KEt/2.303, what does Co stand for _______

(a) Plasma drug concentration after 60 min of i.v. injection

(b) Plasma drug concentration after 15 min of i.v. injection

(c) Plasma drug concentration after 30 min of i.v. injection

(d) Plasma drug concentration immediately after i.v. injection

I have been asked this question during a job interview.

This question is from One & Two Compartment Open Model in portion Compartment Modelling, Non Linear Pharmacokinetics, Bioavailability and Bioequivalence of Drug Biotechnology

Answer 1

Right answer is (d) Plasma drug concentration immediately after i.v. injection

For explanation I would say: In the equation log C = log Co – KEt/2.303, C is the drug concentration in plasma, Co is the plasma drug concentration immediately after i.v. injection, KE is the overall elimination rate constant, t is time.