Question

In the given picture, the marking “a” represents the drug concentration of which compartment?

(a) The central compartment in a two compartment model

(b) A peripheral compartment in a two compartment model

(c) The central compartment in a one compartment model

(d) Drug concentration of the plasma

The question was asked during an interview.

My query is from One & Two Compartment Open Model topic in division Compartment Modelling, Non Linear Pharmacokinetics, Bioavailability and Bioequivalence of Drug Biotechnology

Answer 1

The correct answer is (a) The central compartment in a two compartment model

To explain: In the graph, the marked curve is showing the drug concentration of the central compartment. Initially, the drug concentration of the central compartment in a two compartment model declines rapidly because of the rapid distribution of the drug from the central compartment to the peripheral compartment. This phase is known as the distributive phase.