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What does the word “open” mean in the one compartment open model?

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What does the word “open” mean in the one compartment open model?

(a) The drug easily enters

(b) The drug readily mixes with the blood

(c) Unidirectional input and output

(d) Easy absorption

This question was addressed to me by my school principal while I was bunking the class.

My question is taken from One & Two Compartment Open Model in section Compartment Modelling, Non Linear Pharmacokinetics, Bioavailability and Bioequivalence of Drug Biotechnology

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Correct option is (c) Unidirectional input and output

Explanation: The term open indicates that the input and the output are unidirectional and the drug can be eliminated from the body. One compartment open model does not assume that drug concentration in plasma is equal to that in other body tissue.

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