Question

In noncompartmental analysis, Mean residence time is equal to _____________

(a) The area under the first moment curve/area under the zero moment curve

(b) The area under the zero moment’s curve/area under the first moment curve

(c) 1 / Area under the first-moment curve

(d) 1/ Area under the zero moment curve

I had been asked this question in unit test.

Query is from Pharmacokinetic Models topic in division Pharmacokinetic Drug Interactions & Basic Considerations of Drug Biotechnology

Answer 1

The correct answer is (a) The area under the first moment curve/area under the zero moment curve

To explain: For noncompartmental analysis, the mean residence time is equal to the area under the first moment curve (AUMC) / area under the zero moment curve (AUC). AUMC is obtained from a plot of plasma drug concentration and time versus time t.