Question

What type of drug administration will have the shown compartment model?

(a) Intravenous administration

(b) Oral administration

(c) Rectal administration

(d) Sublingual administration

I had been asked this question at a job interview.

The query is from Pharmacokinetic Models in chapter Pharmacokinetic Drug Interactions & Basic Considerations of Drug Biotechnology

Answer 1

Right option is (a) Intravenous administration

Explanation: There is no arrow entering the 1^st compartment itself, this means whatever the administration is it directly goes into the blood. In intravenous administration, the blood is considered to be the 1^st compartment, this blood will be moving to organs like lungs, kidneys, liver, etc. Since one single compartment is shown it will be intravenous administration. Ko1 is the rate constant, i.e. the first order absorption rate constant and K10 is the first order elimination rate constant. The 2nd compartment is for the organs with poor perfusion.