Question

Which of the following will be a disadvantage for the physiologic model?

(a) Prediction of drug concentration in various body regions

(b) Correlation of data in several animal species

(c) Obtaining experimental data for each of the organs

(d) The model gives an exact description of the drug concentration-time profile for any organ

This question was addressed to me in exam.

The query is from Pharmacokinetic Models topic in section Pharmacokinetic Drug Interactions & Basic Considerations of Drug Biotechnology

Answer 1

Right option is (c) Obtaining experimental data for each of the organs

Easiest explanation: The advantages of physiologic model are, concentration of the drug in various body parts can be predicted on the basis of organ or tissue volume, the model gives an exact description of the drug concentration-time profile for any organ, correlation of data in several animal species is possible and the disadvantage is that obtaining experimental data for each an every organ is difficult.