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Which model is also known as membrane permeation rate limited?

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Which model is also known as membrane permeation rate limited?

(a) Physiologic model

(b) Compartment model

(c) Noncompartment model

(d) Mammillary model

This question was addressed to me during an internship interview.

This key question is from Pharmacokinetic Models in division Pharmacokinetic Drug Interactions & Basic Considerations of Drug Biotechnology

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Right choice is (a) Physiologic model

Easy explanation: Physiologic models are made with the assumption that the drug movement within a body region is much more rapid than its rate of delivery to that region, this assumption will be applicable to highly membrane permeable drugs i.e. drugs with low molecular weight, nonionized and lipophilic drugs. For highly polar, ionized and charged drugs, the model is referred to as membrane permeation rate-limited.

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