Question

In the below picture which form of solid solution of griseofulvin with succinic acid is shown?

(a) Solid solution

(b) Eutectic mixture

(c) Micronized drug

(d) Coarse drug

The question was posed to me during an interview.

The doubt is from Bioavailability in portion Compartment Modelling, Non Linear Pharmacokinetics, Bioavailability and Bioequivalence of Drug Biotechnology

Answer 1

The correct option is (c) Micronized drug

The best explanation: Solid solutions are prepared by fusion method where a mixture of solute and solvent are melted together followed by rapid solidification. Such systems are prepared by fusion and are called as melts e.g. griseofulvin-succinic acid. Solid solution is binary system with solid solute dispersed in solid solvent. Eutectic mixtures are physically blended mixture of two crystalline compound.