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The urinary excretion of the unchanged drug is directly proportional to the plasma concentration of a drug.

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The urinary excretion of the unchanged drug is directly proportional to the plasma concentration of a drug.

(a) True

(b) False

The question was asked in an internship interview.

The origin of the question is Bioavailability in section Compartment Modelling, Non Linear Pharmacokinetics, Bioavailability and Bioequivalence of Drug Biotechnology

1 Answer

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Correct option is (a) True

Easy explanation: Urinary excretion studies help in assessing bioavailability is based on the principle that urinary excretion of unchanged drug is directly proportional to the plasma concentration of a drug. If a drug is excreted at least 10 to 20% in the urine, bioavailability can be determined.

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