Question

To have a plasma distribution value of 900 ml and plasma drug concentration to be 1.2 mg/ml what should be the amount of drug that should be given to the patient?

(a) 1080 ml

(b) 1080 g

(c) 1080 mg

(d) 1g/ml

The question was posed to me by my school teacher while I was bunking the class.

Asked question is from One & Two Compartment Open Model topic in division Compartment Modelling, Non Linear Pharmacokinetics, Bioavailability and Bioequivalence of Drug Biotechnology

Answer 1

Correct answer is (c) 1080 mg

Easy explanation: The apparent volume of distribution Vd is given by Amount of drug in the body (X) / plasma drug concentration (C). Vd is expressed in liters or ml. to find out the amount of drug, the equation is the apparent volume of distribution (Vd)*plasma drug concentration (C).