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Which of the following responsible for inflammatory response mainly?

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Which of the following responsible for inflammatory response mainly?

(a) COX 1

(b) COX 2

(c) COX 3

(d) COX 4

This question was posed to me in an interview.

Asked question is from Drug Addiction and Abuse topic in chapter Local & General Anesthetics, Opioid Analgesics, Drug Addiction and Drug Abuse of Drug Biotechnology

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Correct choice is (b) COX 2

To elaborate: Cyclooxygenase-1 (COX-1) constitutively expressed in a wide variety of cells all over the body and thus known as “housekeeping enzyme” e.g.  Gastric cytoprotection. Cyclooxygenase-2 (COX-2), inducible enzyme an immediate-early gene product in inflammatory and immune cells it is dramatically up-regulated during inflammation.

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