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Which of the following drugs are lipid soluble?

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Which of the following drugs are lipid soluble?

(a) Phenytoin

(b) Caffeine

(c) Digoxin

(d) Antibiotics

I had been asked this question in an online quiz.

This key question is from Pharmacokinetic Principles Applications topic in portion Applications of Pharmacokinetic Principles, Diuretics, Drug Concentration and Pharmacologic Response of Drug Biotechnology

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Right option is (a) Phenytoin

To explain I would say: Drugs such as phenytoin, diazepam, and thiopental are lipid soluble, these drugs get distributed to the adipose tissue more, and thus increases the volume of distribution. In obese patients’ volume of distribution is larger per kg body weight and thus requires larger doses more than total body weight basis.

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