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Which hormone is a major contributor for increasing vascular permeability during inflammation?

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Which hormone is a major contributor for increasing vascular permeability during inflammation?

(a) Histamine

(b) Serotonin

(c) Bradykinin

(d) Leukotrienes

The question was asked in unit test.

Asked question is from Drug Addiction and Abuse in portion Local & General Anesthetics, Opioid Analgesics, Drug Addiction and Drug Abuse of Drug Biotechnology

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The correct choice is (a) Histamine

Easiest explanation: The hormone that acts as a major contributor for increasing vascular permeability during inflammation is histamine. In most cases, it is observed that histamine tends to increase vascular permeability by (NO)-dependent vascular dilation and also with increased blood flow.

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