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Which hormone is a major contributor to vasodilation during inflammation reaction?

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Which hormone is a major contributor to vasodilation during inflammation reaction?

(a) Histamine

(b) Serotonin

(c) Bradykinin

(d) Leukotrienes

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This is a very interesting question from Drug Addiction and Abuse in chapter Local & General Anesthetics, Opioid Analgesics, Drug Addiction and Drug Abuse of Drug Biotechnology

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Correct option is (c) Bradykinin

Easiest explanation: Bradykinin major contributors to symptoms of inflammation, it helps to increase the vasodilation during inflammation reaction. Leukotrienes increase vascular permeability and increase mobilization of endogenous mediators of inflammation. Prostaglandins promote edema and leukocyte infiltration and increase vascular permeability, enhance pain producing properties of bradykinin.

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