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Which hormone is a major contributor for pain during inflammation reaction?

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Which hormone is a major contributor for pain during inflammation reaction?

(a) Histamine

(b) Serotonin

(c) Bradykinin

(d) Leukotrienes

The question was asked during a job interview.

The query is from Drug Addiction and Abuse in division Local & General Anesthetics, Opioid Analgesics, Drug Addiction and Drug Abuse of Drug Biotechnology

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The correct answer is (c) Bradykinin

Easiest explanation: Bradykinin major contributors to symptoms of inflammation it is the main cause behind pain. Leukotrienes increase vascular permeability and iincrease mobilization of endogenous mediators of inflammation. Prostaglandins increase the vascular permeability, enhance pain producing properties of bradykinin.

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