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Which of the following cannot be tolerated, rheumatoid arthritis patient?

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Which of the following cannot be tolerated, rheumatoid arthritis patient?

(a) Piroxicam

(b) Phenylbutazone

(c) Ibuprofen

(d) Indomethacin

I got this question by my school teacher while I was bunking the class.

This key question is from Drug Addiction and Abuse in chapter Local & General Anesthetics, Opioid Analgesics, Drug Addiction and Drug Abuse of Drug Biotechnology

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Right option is (d) Indomethacin

The explanation is: Phenylbutazone is a powerful anti-inflammatory drug. Piroxicam has a half-life of 45 hours and thus can be administered once a day. Ibuprofen is a propionic acid derivative has the same potency as acetyl Salicylate but better tolerated. Indomethacin is an indole derivative more potent than ASA but inferior at doses tolerated by rheumatoid arthritis patients, quite toxic.

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