Question

Which of the following histamine receptor increase permeability during inflammation reaction?

(a) H1 receptor

(b) H2 receptor

(c) H3 receptor

(d) H4 receptor

This question was posed to me during an interview for a job.

Origin of the question is Drug Concentration and Pharmacologic Response in section Applications of Pharmacokinetic Principles, Diuretics, Drug Concentration and Pharmacologic Response of Drug Biotechnology

Answer 1

Correct option is (a) H1 receptor

Best explanation: A drug that reduces or eliminates the effects mediated by the chemical histamine. The term antihistamine only refers to H1 receptor antagonists. H1 receptors mediate an increase in vascular permeability at sites of inflammation induced by histamine. Antihistamine cannot remove the histamine if it is already bound.