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Which of the following is ultra-short-acting insulin analogue?

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Which of the following is ultra-short-acting insulin analogue?

(a) Detemir

(b) Insulin aspart

(c) Insulin NPH

(d) Glargine

The question was posed to me in an internship interview.

My question is based upon Controlled Release Medication topic in section Controlled Release Medication of Drug Biotechnology

1 Answer

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Correct option is (b) Insulin aspart

Explanation: It was approved by the FDA in 2000. Insulin aspart has a rapid onset and short duration of glucose lowering activity. The amino acid, B28 of the parent chain, which is normally proline, is substituted with an aspartic acid residue making it short-acting insulin. This means this drug has to be taken just before meals.

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