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With aqueous solutions, the drug releases can be controlled. Which of the following is not the right method of controlling?

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With aqueous solutions, the drug releases can be controlled. Which of the following is not the right method of controlling?

(a) Increasing the viscosity

(b) By forming complexes with macromolecules

(c) Reducing the solubility of the parent drug

(d) Increasing the pH to make it highly basic

The question was asked at a job interview.

Question is taken from Biopharmaceuticals in portion Biopharmaceuticals of Drug Biotechnology

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Right option is (d) Increasing the pH to make it highly basic

Best explanation: Both aqueous and oil solutions can be used for controlled drug release. The aqueous solution the release can be controlled by increasing the viscosity of the vehicle by use of MC, CMC, PVP. BY forming complexes with macromolecules like MC, CMC, or PVP. By forming complexes that control drug release not by dissociation but by reducing the solubility of the parent drug.

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