Question

Which of the following is true for monolithic devices?

(a) These devices are used when the drug permeation rate is rapid

(b) The release of the drug is controlled

(c) Suitable for drugs with large therapeutic indices

(d) The drug is contained in a powder form floating on liquid

I have been asked this question in an internship interview.

Enquiry is from Biopharmaceuticals in portion Biopharmaceuticals of Drug Biotechnology

Answer 1

Right answer is (c) Suitable for drugs with large therapeutic indices

For explanation I would say: The drug used in these devices has a large therapeutic index. The drug release rate from the matrix is rapid initially and then falls as the matrix gets depleted of the drug. The polymer employed for the matrix system may be hydrophilic or lipophilic. These polymers include PVC, PVP, and polysaccharides.