Question

The hierarchical approach is ____ and _____ than the shotgun approach because it involves an initial clone-based physical mapping step.

(a) slower, less costly

(b) faster, more costly

(c) faster, less costly

(d) slower, more costly

This question was addressed to me during an interview.

My question comes from Genome Sequencing in portion Genome Mapping, Assembly and Comparison of Bioinformatics

Answer 1

Correct choice is (d) slower, more costly

For explanation: During the era of human genome sequencing, there was a heated debate on the merits of each of the two strategies. Despite the mentioned fact, once the map is generated, assembly of the whole genome becomes relatively easy and less error prone.