Question

The hierarchical genome sequencing approach is ______

(a) entirely dissimilar to the shotgun approach

(b) dissimilar to the shotgun approach

(c) similar to the shotgun approach, but on a larger scale

(d) similar to the shotgun approach, but on a smaller scale

This question was posed to me in quiz.

My doubt is from Genome Sequencing topic in division Genome Mapping, Assembly and Comparison of Bioinformatics

Answer 1

Correct option is (d) similar to the shotgun approach, but on a smaller scale

The explanation: In this, the chromosomes are initially mapped using the physical mapping strategy. Longer fragments of genomic DNA (100 to 300 kB) are obtained and cloned into a high-capacity bacterial vector called bacterial artificial chromosome (BAC).