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The phylogenetic profile method relies on detection of orthologs (or homologs, in a variation of the method) in a set of genomes.

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The phylogenetic profile method relies on detection of orthologs (or homologs, in a variation of the method) in a set of genomes.

(a) True

(b) False

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The question is from The Use of Gene Order & Phylogeny to Predict Protein topic in portion Global Approaches for Studying Protein – Protein Interactions of Bioinformatics

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Correct option is (a) True

Explanation: If the pattern of ortholog presence or absence is the same in a group of proteins, then these proteins are clustered together as belonging to the same functional class. A method that appears to reliably predict a loose functional correlation between proteins is the phylogenetic profile method developed by Pellegrini and colleagues.

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