Question

Which of the following is untrue about PhyloCon?

(a) It stands for Phylogenetic Consensus

(b) It is used to identify regulatory motifs

(c) It is a UNIX program that combines phylogenetic footprinting with gene expression profiling analysis

(d) No conservation among orthologous genes and conservation among coregulated genes is a disadvantage

I got this question in final exam.

This interesting question is from Prediction Algorithms in portion Promoter and Regulatory Element Prediction of Bioinformatics

Answer 1

The untrue statement about PhyloCon is:

(d) No conservation among orthologous genes and conservation among coregulated genes is a disadvantage.

This statement is untrue because PhyloCon is specifically designed to address the conservation of regulatory motifs among coregulated genes. It combines phylogenetic footprinting and gene expression profiling to predict regulatory elements. The method relies on identifying conserved motifs that are shared by genes that are coregulated across species, which is a key advantage of the tool.

So, statement (d) does not accurately describe PhyloCon's purpose and approach.