Question

Due to the requirement for co-regulation as well as colocalization, the method is mostly limited to certain classes of protein-protein interactions.

(a) True

(b) False

The question was asked during an interview.

This key question is from The Use of Gene Order & Phylogeny to Predict Protein topic in section Global Approaches for Studying Protein – Protein Interactions of Bioinformatics

Answer 1

Right choice is (a) True

Best explanation: Those classes are members of the same stable complex and proteins in the same metabolic pathway. In their assessment of computational methods for prediction of all types of protein interactions, Huynen and colleagues found that two-thirds of the interactions detected in this way were between proteins that physically interact and another 15% between proteins part of the same metabolic pathway. The remaining interactions involved hypothetical proteins of unknown function.