Question

Which of the given statement is incorrect?

(a) The predicted set of proteins for the genome is referred to as the proteome

(b) The amino acid sequence of proteins encoded by the predicted genes is used as a query of the protein sequence databases in a database similarity search

(c) A match of a predicted protein sequence to one or more database sequences   serves only to identify the gene function but it doesn’t validate the gene prediction

(d) The genome sequence is annotated with the information on gene content and predicted structure, gene location, and functional predictions

This question was addressed to me in final exam.

I want to ask this question from Sequence Assembly and Gene Identification in chapter Collecting & Storing Sequences in Laboratory of Bioinformatics

Answer 1

Right choice is (c) A match of a predicted protein sequence to one or more database sequences   serves only to identify the gene function but it doesn’t validate the gene prediction

Easiest explanation: A match of a predicted protein sequence to one or more database sequences not only serves to identify the gene function, but also validates the gene prediction. Pseudogenes, gene copies that have lost function, may also be found in this analysis.