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GATC sequence on either side of the mismatch can help in MMR.

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GATC sequence on either side of the mismatch can help in MMR.

(a) True

(b) False

I had been asked this question in examination.

This key question is from Repair of DNA Damage: MMR, BER topic in section DNA Mutation, DNA Repair, Transposable Elements of Cytogenetics

1 Answer

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Best answer
Right choice is (a) True

Explanation: Mut H binds to hemimethylated GATC sequences, and such sequences on either side of the mismatch can help in MMR. Although even a GATC 1000bp away can help determine the correct stand to cut, it efficiency reduces with increasing distance.

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